The importance of understanding amylin signaling mechanisms for therapeutic development in the treatment of Alzheimer's disease

S Servizi, RR Corrigan… - Current pharmaceutical …, 2020 - ingentaconnect.com
… suggested amylin binding in the hippocampus [83, 87-89]. … to be mediated through the
TRPV4 receptor; as TRPV4 receptor … shares neurotoxic properties with Abeta42 in long-term

An unbalanced synaptic transmission: cause or consequence of the amyloid oligomers neurotoxicity?

M Sciaccaluga, A Megaro, G Bellomo… - International Journal of …, 2021 - mdpi.com
… induce NGFR -mediated neuronal death through the p75 neurotrophin receptor, which is
a … NMDA-dependent long term potentiation (LTP) induction in the hippocampal CA1 and …

Amylin and amylin receptors in Alzheimer's disease

W Fu, JH Jhamandas - Genetics, Neurology, Behavior, and Diet in …, 2020 - Elsevier
Long-term potentiation (LTP) is a process involving persistent … felt to be mediated by neuronal
amylin receptors, a notion … , cAC253, to amylin receptors within the hippocampus. These in …

Extracellular vesicles enriched with amylin receptor are cytoprotective against the Aß toxicity in vitro

R Soudy, R Kimura, W Fu, A Patel, J Jhamandas - Plos one, 2022 - journals.plos.org
… Aβ oligomer-mediated long term potentiation (LTP) impairment in mouse hippocampal slices
[… Effects of AMY3 EVs on Aβ-induced depression of hippocampal long term potentiation (LTP…

Genetic depletion of amylin/calcitonin receptors improves memory and learning in transgenic Alzheimer's disease mouse models

A Patel, R Kimura, W Fu, R Soudy, D MacTavish… - Molecular …, 2021 - Springer
… to human amylin- and Aβ-induced depression of hippocampal long-term potentiation (LTP) …
of these target receptors for Aβ could attenuate the amyloid-induced neuroinflammation, …

Role of receptors in relation to plaques and tangles in Alzheimer's disease pathology

K Sharma, S Pradhan, LK Duffy, S Yeasmin… - International Journal of …, 2021 - mdpi.com
… , including long-term depression (LTD), long-term potentiation (… receptors mediate Aβ induced
neurotoxicity in hippocampal … ) and human amylin on hippocampal long-term potentiation (…

Insulin and insulin resistance in Alzheimer's disease

A Sędzikowska, L Szablewski - International journal of molecular sciences, 2021 - mdpi.com
… in hippocampal synaptic plasticity by favoring long-term … -mediated downregulation of
hypothalamic insulin receptors … associated with long-term depression and long-term potentiation, …

Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies

K Xhima, K Markham-Coultes, R Hahn Kofoed… - Brain, 2022 - academic.oup.com
… , avoid activation through the p75 neurotrophin receptor (p75 … ’s disease and their long-term
use may also have disease-… a treatment paradigm using MRIgFUS-mediated delivery of …

The use of bioactive compounds in hyperglycemia-and amyloid fibrils-induced toxicity in type 2 diabetes and Alzheimer's disease

AV Lupaescu, M Iavorschi, M Covasa - Pharmaceutics, 2022 - mdpi.com
… satiety through a centrally mediated mechanism [16]. However, in diabetic patients, amylin
… The protective effects of UA against β-amyloid-induced neurotoxicity were confirmed in …

Oleuropein Promotes Neural Plasticity and Neuroprotection via PPARα-Dependent and Independent Pathways

F Malliou, CE Andriopoulou, A Kofinas, A Katsogridaki… - Biomedicines, 2023 - mdpi.com
… OLE-mediated down-regulation of BDNF in the hippocampus. … which control the memory
and long-term potentiation (LTP) of … of OLE against β-amyloid-induced toxicity was unrelated to …